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The New England Journal of Medicine: Search Results for multiple sclerosis
content.nejm.org
2
The New England Journal of Medicine (NEJM) RSS feed -- Search Results for multiple sclerosis. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.
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Risk of Natalizumab-Assoc iated Progressive Multifocal Leukoencephalopat hy

Natalizumab (Tysabri, Biogen Idec and Elan Pharmaceuticals) is approved for the treatment of relapsing–remitting multiple sclerosis in more than 50 countries and also for the treatment of moderate-to...

17 may 12

Placebo-Controlle d Trial of Oral Laquinimod for Multiple Sclerosis

…multiple sclerosis but withdrawn because of safety concerns. Preclinical studies have shown that laquinimod reduces inflammatory cell infiltrates in the central nervous system, decreases demy...

15 mar 12

Fingolimod for Multiple Sclerosis

…authors clinical recommendations. Stage. A 37-year-old man with multiple sclerosis was evaluated for consideration of oral immunotherapy. Six years earlier, he had reported acute monocular vi...

26 jan 12

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

Diagnostic, therapeutic, and investigative efforts in multiple sclerosis have concentrated on disease of the white matter. Imaging and histopathological studies suggest that cortical damage is a corr...

08 dec 11

Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis

Teriflunomide, the active metabolite of leflunomide, is being investigated as a new oral disease-modifying therapy for relapsing forms of multiple sclerosis. Although the two drugs are related in str...

06 oct 11

Oral Cladribine and Fingolimod for Relapsing Multiple Sclerosis

…Multiple Sclerosis Correspondence, N Engl J Med 2010:362;1738-1740. In the letter to the Editor from Li and Zhang (page 1739), the first reference cited should have been “Polman CH, OConnor P...

15 jul 10

Oral Cladribine and Fingolimod for Relapsing Multiple Sclerosis

To the Editor: In the three trials for relapsing multiple sclerosis (Feb. 4 issue),– a drug of established efficacy was used as a comparison drug in only one trial. In the other two trials,, a total ...

06 may 10

Oral Therapy for Multiple Sclerosis — Sea Change or Incremental Step?

The long-awaited arrival of oral formulations for the treatment of relapsing–remitting multiple sclerosis is welcome news for the estimated 2.5 million people worldwide who have this chronic, disabli...

04 feb 10

A Placebo-Controlle d Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

Fingolimod (FTY720) is an oral sphingosine-1-phosphate–recept or modulator that is currently being evaluated for the treatment of multiple sclerosis. There is evidence that fingolimod acts by preventi...

04 feb 10

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

…effects.– Fingolimod effectively treats experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. In a 6-month, phase 2 study involving patients with relapsing multipl...

04 feb 10

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

…9 Fingolimod effectively treats experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. 1 10 11 In a 6-month, phase 2 study involving patients with relapsing multipl...

04 feb 10

B-Cell-Depleting Induction Therapy and Acute Cellular Rejection

…depletion is an effective treatment for a number of autoimmune diseases in which B cells were not previously considered to be important, such as multiple sclerosis. 1 In renal transplantation...

18 jun 09

Case 17-2009: A 30-Year-Old Man with Progressive Neurologic Deficits

…radiologic appearance but does not typically recur; the predominant involvement of basal ganglia does not rule out a demyelinating process such as multiple sclerosis, but such a process would...

28 may 09

Case 1-2009: A 57-Year-Old Man with Progressive Cognitive Decline

…adults with leukodystrophies remain undiagnosed, in part because their symptoms are attributed to substance abuse or other disorders such as multiple sclerosis and fibromyalgia. Discussion of...

08 jan 09

Case 40-2008: A 26-Year-Old Man with Blurred Vision

…optic-nerve dysfunction in young adults. Although it is most common in patients with multiple sclerosis, it may occur as an isolated phenomenon; when it does, it is often followed by the deve...

25 dec 08

Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis

Multiple sclerosis typically follows a relapsing-remitting course, but most patients eventually convert to a secondary progressive phase characterized by deficits that increase in the absence of furt...

23 oct 08

Relapse, Remission, and Progression in Multiple Sclerosis

Multiple sclerosis is the most common cause of severe neurologic disability in adults of northern European origin. At postmortem examination, the cardinal pathological features are multiple areas of ...

22 jun 08

Autoimmune Diseases

…living in different conditions strongly suggest the importance of environmental triggers. For example, the incidence of both type 1 diabetes and multiple sclerosis in a population changes as ...

03 jan 08

Sarcoidosis

…of patients, oligoclonal immunoglobulin bands in the cerebrospinal fluid are elevated, making it difficult to differentiate sarcoidosis from multiple sclerosis. 74 Magnetic resonance imaging ...

22 nov 07

Case 4-2007: A 56-Year-Old Woman with Rapidly Progressive Vertigo and Ataxia

…good health. Her mother had had breast cancer in her eighth decade, and her father had Parkinson's disease. There was no family history of multiple sclerosis. Medications included atorvastati...

08 feb 07

Lack of Association between Antimyelin Antibodies and Progression to Multiple Sclerosis

…dysfunction that is suggestive of multiple sclerosis (known as a clinically isolated syndrome), it is difficult to predict the individual risk of multiple sclerosis. Berger et al. 1 reported ...

25 jan 07

Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

Multiple sclerosis is the most common nontraumatic cause of neurologic disability in young adults. 1 2 It is generally believed to be an autoimmune condition in which autoreactive T cells attack myel...

14 sep 06

Relapses and Progression of Disability in Multiple Sclerosis

Multiple sclerosis is the most common chronic disabling disease of the central nervous system in young adults. It affects 1 in 1000 people in Western countries. 1 It is primarily characterized by mul...

31 aug 06

Multiple Sclerosis as a Neuronal Disease

…reader may wonder if the intent is to develop a theory of multiple sclerosis as a primary axonal disease, as some investigators have suggested. Actually, the editor writes in the preface that...

22 sep 05

A Longitudinal Study of Abnormalities on MRI and Disability from Multiple Sclerosis

…isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, multiple sclerosis can develop months or many years lat...

30 jan 05

Molecular Mimicry in Multiple Sclerosis

…multiple sclerosis is an autoimmune disease in which T cells recognize and attack components of the axonal myelin sheath and other features of the central nervous system, destroying myelin an...

10 jul 03

Natalizumab for Relapsing Multiple Sclerosis

…integrin antibody was of clinical benefit. Miller and colleagues ( Jan. 2 issue) 2 report that monthly natalizumab infusions in patients with multiple sclerosis significantly reduced relapse ...

17 apr 03

Case 10-2002: A 52-Year-Old Woman with Recurrent Unsteadiness, Slurred Speech, and Fatigue

…loss of consciousness, and weakness or numbness of the arms and legs. This patient's history does not support such a diagnosis. Likewise, in multiple sclerosis, there may be an acute onset of...

17 jan 02

Principles of Neuroepidemiology

…executed study may not be relevant to many clinical practices. Multiple sclerosis is the crown jewel of neuroepidemiology. To any physician interested in following the medical detective story...

17 jun 01

Multiple Sclerosis

More than 100 years has passed since Charcot, Carswell, Cruveilhier, and others described the clinical and pathological characteristics of multiple sclerosis. 1 This enigmatic, relapsing, and often e...

31 jan 88

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