How much cost Imatinib price in USA & Philippines

Imatinib is most affordable to buy in the form of Gleevec , a pack of 120 capsules with a dosage of 100 mg will cost an average of 7500-9000 INR & Imatinib price in USA average $250 to $300

How much cost Imatinib mesylate tablets buy online USA & Philippines

One Imatinib mesylate tablets with a coating in the form of a shell may contain 50 mg of imatinib (used in the form of mesylate ) and 65.2 mg of low substituted hyprolose, 0.285 mg of povidone, 21 mg of sodium carboxymethyl starch, 1.9 mg of colloidal silicon dioxide, 1.035 mg of stearate magnesium. The shell components are 6.84 mg opadry yellow, 0.36 mg opadry red.

One tablet may contain 100 or 400 mg of imatinib (used in the form of mesilate ) and auxiliary anhydrous lactose, croscarmellose sodium, povidone K30, talc, magnesium stearate and crospovidone. The composition of the shell includes: Insta-Coat film coating (polyethylene glycol, hypromellose , talc, titanium dioxide (E171), dye (E172) - 0.5 mg of iron (III) red oxide).

One capsule contains 100 mg of imatinib (used in the form of mesylate ) and auxiliary anhydrous lactose, crospovidone, colloidal silicon dioxide and magnesium stearate. The capsule shell is made of titanium dioxide (E 171) and gelatin.

Dosage

Tablets dosages of 50 mg have a brown-orange color, a biconvex round shape and engraving "50". In one carton of 30 tablets, sealed in a cellular plate of 10 tab.

The tablets with a dosage of 100 and 400 mg have a brown-pink color, a biconvex oblong shape, differ in engraving 100 and 400, respectively. Tablets are sealed in cellular packages of 10 tab. or in polymer cans of 10, 20, 24, 30, 36, 48, 50, 60, 96, 100, 120, 180 tab.

The drug is also available in hard gelatin capsules with a dosage of 100 mg, sealed in 10 pieces in blisters. In one pack 30 capsules. Capsules Imatinib Teva (Israeli production) can be distinguished from domestic capsules on the label «TEVA» on the lid.

Pharmacodynamics and pharmacokinetics

Imatinib is an anticancer drug; it is by its nature an inhibitor of an abnormal enzyme , protein tyrosine kinase , which is produced by the Philadelphia chromosome 22 in chronic myeloid leukemia .

Imatinib is a potent inhibitor of tyrosine kinase receptors for growth factors of platelets and stem cells, as well as c-Kit. Imatinib is able to inhibit proliferation and induce apoptosis of stromal neoplasm cells in the gastrointestinal tract that express kit mutations.

These pharmacokinetic studies

After oral ingestion, Imatinib undergoes absorption, its bioavailability is high - 98%. For achievement of the maximum concentration 2-4 hours are necessary. Binding to plasma proteins in the bloodstream occurs at 95%. Metabolism occurs predominantly in the liver and requires the participation of the CYP3A4 enzyme and others (at least CYP1A2, CYP2D6, CYP2C19, CYP2C9 ) from the Cytochrome P450 system . As a result, the main active metabolite is formed - N-demethylated piperazine derivative (its AUC is 15%). Imatinib has a half-life of 18 hours, its metabolite is 40 hours. The drug is mainly excreted with feces 68%, 13% along with urine.

Contraindications

The presence of hypersensitivity reactions to any of the components of Imatinib.

There is no data on the safety and efficacy of use in children under 3 years of age. With caution it is necessary to use the drug in patients with impaired liver function, since it is possible to enhance the effect of this antitumor agent

Imatinib price & where to buy USA, Philippines & India

Imatinib is most affordable to buy in the form of Gleevec , a pack of 120 capsules with a dosage of 100 mg will cost an average of 7500-9000 INR & Imatinib price in USA average $250 to $300